Claire and Moira are knocked unconscious and awaken later to find themselves in a dark and abandoned detention facility. Moira Burton, is attending her welcome party for Terra Save when unknown armed forces storm the office.

Survivor of the Raccoon City incident depicted in previous Resident Evil games, Claire now works for the anti-bioterrorism organization Terra Save. The beginning of the Resident Evil Revelations 2 tale sees fan favorite Claire Redfield make a dramatic return.